脂质载体结合微针在经皮给药中的应用

郭腾,张永太,赵继会,冯年平

中国药学杂志 ›› 2015, Vol. 50 ›› Issue (13) : 1085-1089.

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中国药学杂志 ›› 2015, Vol. 50 ›› Issue (13) : 1085-1089. DOI: 10.11669/cpj.2015.13.003
·综 述·

脂质载体结合微针在经皮给药中的应用

  • 郭腾,张永太,赵继会,冯年平*
作者信息 +

Application of Lipid Carriers Combining Microneedle in Transdermal Drug Delivery

  • GUO Teng, ZHANG Yong-tai, ZHAO Ji-hui, FENG Nian-ping*
Author information +
文章历史 +

摘要

脂质载体结合微针的给药方式是一种新型的经皮给药方式,通过微针突破皮肤屏障的同时以载体材料的包裹延长药物的释放,提高药物的稳定性及减少药物的毒副作用和皮肤刺激性,为中药经皮给药制剂的开发带来了新的发展机遇。笔者根据近年来国内外相关的研究报道,对脂质载体结合微针的促透机制、给药方式和影响药物透皮吸收的因素进行归纳总结,综述了脂质载体结合微针在经皮给药中的应用进展。

Abstract

ABSTRACT: As a new type of transdermal drug delivery, microneedles can transiently break the barrier properties of skin and the lipid carriers offer a wide range of benefits including control of skin permeation, protection of the encapsulated drug and decrease of the drug toxicity and skin irritation, lipid carriers combining microneedle will bring new opportunities for developing transdermal drug delivery preparations of traditional chinese medicine. By researching the relevant literatures at home and abroad,the enhancing mechanisms, administration and influence for percutaneous absorption of lipid carriers combining microneedle were reviewed and the application of lipid carriers combining microneedle in transdermal drug delivery was summarized.

关键词

微针 / 脂质载体 / 经皮给药

Key words

microneedle / lipid carrier / transdermal drug delivery

引用本文

导出引用
郭腾,张永太,赵继会,冯年平. 脂质载体结合微针在经皮给药中的应用[J]. 中国药学杂志, 2015, 50(13): 1085-1089 https://doi.org/10.11669/cpj.2015.13.003
GUO Teng, ZHANG Yong-tai, ZHAO Ji-hui, FENG Nian-ping. Application of Lipid Carriers Combining Microneedle in Transdermal Drug Delivery[J]. Chinese Pharmaceutical Journal, 2015, 50(13): 1085-1089 https://doi.org/10.11669/cpj.2015.13.003
中图分类号: R944   

参考文献

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